Resting-State fMRI Functional Connectivity Is Associated with Sleepiness, Imagery, and Discontinuity of Mind

Resting-State fMRI Functional Connectivity Is Associated with Sleepiness, Imagery, and Discontinuity of Mind

Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate the functional architecture of the healthy human brain and how it is affected by learning, lifelong development, brain disorders or pharmacological intervention. Non-sensory experiences are prevalent during rest and must arise from ongoing brain activity, yet little is known about this relationship. Here...

Brain Connections – Resting State fMRI Functional Connectivity

With the introduction of electroencephalography (EEG) in 1930, researchers began to explore spontaneous activity in the brain by recording the individual, independently of any task. Subsequently, evoked potential studies, where electrical potentials were recorded at the onset of a stimulus, marked a milestone in brain research. Utilizing such methods coupled with experimental psychology, resear...

Functional connectivity in resting-state fMRI: Is linear correlation sufficient?

Functional connectivity (FC) analysis is a prominent approach to analyzing fMRI data, especially acquired under the resting state condition. The commonly used linear correlation FC measure bears an implicit assumption of Gaussianity of the dependence structure. If only the marginals, but not all the bivariate distributions are Gaussian, linear correlation consistently underestimates the strengt...

Support vector classification analysis of resting state functional connectivity fMRI

Vascular Modulation of Resting-State fMRI Functional Connectivity

Widely used in resting-state fMRI functional connectivity measurement (fcMRI), the BOLD signal is an indirect measure of neuronal activity, inherently modulated by vascular physiology. Notably, cerebrovascular reactivity (CVR) varies across individuals irrespective of neuronal changes, with unknown implications, compromising fcMRI interpretation. This work quantifies the relationship between CV...